Solid-state development

During the pre-clinical discovery process, very little effort is normally spent on investigating the solid-state properties of the active ingredient. All too often, this results in adverse effects to critical drug parameters such as solubility, bioavailability and stability. For this reason, we believe it is crucial that the proper solid-state form is developed before entering into clinical trials.

Intelligent crystallization

At Syntagon, we offer a fully non-automated approach to all our solid-state services. With our unique screening procedure, using colloidal dispersion techniques and monitoring by light microscopy, every experiment receives our full attention. In fact, a real expert – not a machine – will be responsible for monitoring and drawing conclusions from each experiment. Having followed this approach for more than twenty years, we know that it provides the best results.

  • Concerned about the solubility of your API? We offer improved solubility, bioavailability, stability and handling properties by finding the proper salt form of your drug candidate.
  • Suffering from long filtrations times? Our unique spherical crystallization methodology solves this problem rapidly, and effectively.>>Read more
    Has chromatographic separation of your enantiomers become too costly? Allow us to develop an inexpensive resolution process instead.
  • Experiencing problems with the crystallization of your compound? We have a 98% success rate in crystallizing over 200 APIs. >>Read more